Difference between revisions of "Skin laxity"
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==Collagen== | ==Collagen== | ||
− | Collagen is damaged by sunlight exposure, dietary [http://www.waiwiki.org/index.php?title=Maillard_reaction AGEs/ALEs] and free radicals in general. Elevated exposure will accelerate age-related exhaustion of collagen production. Solar UV irradiation causes photoaging, characterized by fragmentation and reduced production of type I collagen fibrils that provide strength to skin.[http://www.ncbi.nlm.nih.gov/pubmed/24305962] Long-term exposure to sunlight, including ultraviolet A and B, produces signs associated with photoaging and photodamage, including laxity.[http://www.ncbi.nlm.nih.gov/pubmed/25607696] Exposure to UV-B irradiation suppresses collagen synthesis. Daily life low-dose UV-A1 exposures promote photoaging by affecting collagen breakdown. Responsive darkening of the skin does not prevent UV-A1-induced collagenolytic changes.[http://www.ncbi.nlm.nih.gov/pubmed/24305962] | + | Collagen is damaged by sunlight exposure, endogenous- and dietary [http://www.waiwiki.org/index.php?title=Maillard_reaction AGEs/ALEs] and free radicals in general. Elevated exposure will accelerate age-related exhaustion of collagen production. Solar UV irradiation causes photoaging, characterized by fragmentation and reduced production of type I collagen fibrils that provide strength to skin.[http://www.ncbi.nlm.nih.gov/pubmed/24305962] Long-term exposure to sunlight, including ultraviolet A and B, produces signs associated with photoaging and photodamage, including laxity.[http://www.ncbi.nlm.nih.gov/pubmed/25607696] Exposure to UV-B irradiation suppresses collagen synthesis. Daily life low-dose UV-A1 exposures promote photoaging by affecting collagen breakdown. Responsive darkening of the skin does not prevent UV-A1-induced collagenolytic changes.[http://www.ncbi.nlm.nih.gov/pubmed/24305962] |
Resveratrol has antioxidant properties and promotes autophagy, stimulating mitochondrial biogenesis. Topically applied Resveratrol (1%) in combination with vitamin E (1%) and baicalin (0.5%) may reduce skin laxity in 12 weeks.[http://www.ncbi.nlm.nih.gov/pubmed/25607790] Topically applied Pogostemon cablin may inhibit UV-induced photaging, due to its antioxidative property.[http://www.ncbi.nlm.nih.gov/pubmed/24747030] | Resveratrol has antioxidant properties and promotes autophagy, stimulating mitochondrial biogenesis. Topically applied Resveratrol (1%) in combination with vitamin E (1%) and baicalin (0.5%) may reduce skin laxity in 12 weeks.[http://www.ncbi.nlm.nih.gov/pubmed/25607790] Topically applied Pogostemon cablin may inhibit UV-induced photaging, due to its antioxidative property.[http://www.ncbi.nlm.nih.gov/pubmed/24747030] | ||
Radiofrequency produces thermal effects at various depths, promoting collagen remodeling while sparing the overlying tissue.[http://www.ncbi.nlm.nih.gov/pubmed/25594130] Precise and controlled subdermal heating may promote subdermal skin tightening.[http://www.ncbi.nlm.nih.gov/pubmed/25607794] Radiofrequency may be more effective than cutaneous and subcutaneous administration of CO<sub>2</sub>[http://www.ncbi.nlm.nih.gov/pubmed/25549818] | Radiofrequency produces thermal effects at various depths, promoting collagen remodeling while sparing the overlying tissue.[http://www.ncbi.nlm.nih.gov/pubmed/25594130] Precise and controlled subdermal heating may promote subdermal skin tightening.[http://www.ncbi.nlm.nih.gov/pubmed/25607794] Radiofrequency may be more effective than cutaneous and subcutaneous administration of CO<sub>2</sub>[http://www.ncbi.nlm.nih.gov/pubmed/25549818] |
Revision as of 12:03, 27 January 2015
Skin laxity may be caused by loose skin due to
- redundant skin after rapid weight loss
- damaged collagen and reduced collagen production in ageing
- reduced muscle tone due to immobility
... in combination with heavy skin due to:
- water retention in the true skin
- subcutaneous fat accumulation
Collagen
Collagen is damaged by sunlight exposure, endogenous- and dietary AGEs/ALEs and free radicals in general. Elevated exposure will accelerate age-related exhaustion of collagen production. Solar UV irradiation causes photoaging, characterized by fragmentation and reduced production of type I collagen fibrils that provide strength to skin.[1] Long-term exposure to sunlight, including ultraviolet A and B, produces signs associated with photoaging and photodamage, including laxity.[2] Exposure to UV-B irradiation suppresses collagen synthesis. Daily life low-dose UV-A1 exposures promote photoaging by affecting collagen breakdown. Responsive darkening of the skin does not prevent UV-A1-induced collagenolytic changes.[3] Resveratrol has antioxidant properties and promotes autophagy, stimulating mitochondrial biogenesis. Topically applied Resveratrol (1%) in combination with vitamin E (1%) and baicalin (0.5%) may reduce skin laxity in 12 weeks.[4] Topically applied Pogostemon cablin may inhibit UV-induced photaging, due to its antioxidative property.[5] Radiofrequency produces thermal effects at various depths, promoting collagen remodeling while sparing the overlying tissue.[6] Precise and controlled subdermal heating may promote subdermal skin tightening.[7] Radiofrequency may be more effective than cutaneous and subcutaneous administration of CO2[8]