Difference between revisions of "Heterocyclic Amines (HCA)"
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Many HCA are harmless, or even beneficial (eg vitamins), whereas others, created by cooking or burning, may cause cancer. | Many HCA are harmless, or even beneficial (eg vitamins), whereas others, created by cooking or burning, may cause cancer. | ||
| − | ==HCA in cooked food== | + | ==Carcinogenic HCA in cooked food== |
| − | * 2-amino-3-methylimidazo[4,5-f]quinoline | + | HCAs form when amino acids and creatine react at high cooking temperatures. |
| − | * 2-amino-3,4-dimethylimidazo[4,5-f]quinoline | + | |
| − | * 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline | + | * 2-amino-3-methylimidazo[4,5-f]quinoline (IQ; in broiled sardines, cooked beef) [http://www.ncbi.nlm.nih.gov/pubmed/6733854] |
| − | * 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) | + | * 2-amino-3,4-dimethylimidazo[4,5-f]quinoline [http://www.ncbi.nlm.nih.gov/pubmed/3769138] |
| + | * 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in various cooked foods) [http://www.ncbi.nlm.nih.gov/pubmed/3335050] | ||
| + | * 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP; in cooked meat and fish) [http://www.ncbi.nlm.nih.gov/pubmed/9000552][http://www.ncbi.nlm.nih.gov/pubmed/1860171] | ||
Revision as of 13:57, 7 November 2012
Heterocyclic amines (HCAs) contain at least one heterocyclic ring (with atoms of at least 2 different elements) and one amine group, attached to the heterocyclic ring. Major groups of HCAs are beta-Carbolines, Pyrrolidines, Pyrroles (in Hb and vitamin B12), Pyridines (vitamin B3 and B6) and Pyrimidines (vitamin B1), including Purines (adenine, guanine).
Many HCA are harmless, or even beneficial (eg vitamins), whereas others, created by cooking or burning, may cause cancer.
Carcinogenic HCA in cooked food
HCAs form when amino acids and creatine react at high cooking temperatures.
- 2-amino-3-methylimidazo[4,5-f]quinoline (IQ; in broiled sardines, cooked beef) [1]
- 2-amino-3,4-dimethylimidazo[4,5-f]quinoline [2]
- 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in various cooked foods) [3]
- 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP; in cooked meat and fish) [4][5]
