Difference between revisions of "Male Pattern Baldness"
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Recent research suggests that elevated levels of the enzyme prostaglandin D2 synthase and its product prostaglandin D2 (PGD2) in hair follicles causes androgenetic alopecia. [[http://stm.sciencemag.org/content/4/126/126ra34 Garza A et al]] | Recent research suggests that elevated levels of the enzyme prostaglandin D2 synthase and its product prostaglandin D2 (PGD2) in hair follicles causes androgenetic alopecia. [[http://stm.sciencemag.org/content/4/126/126ra34 Garza A et al]] | ||
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| + | * Prostaglandin D2 synthase (Prostaglandin-H2 D-isomerase (PTGDS) = H-PGDS) converts prostaglandin H2 (PGH2) into prostaglandin D2 (PGD2), so maybe a topical inhibitor of this enzyme will do the trick (to compensate for the elevated level of this enzyme). | ||
| + | ** HQL-79 is a well known, but relatively weak H-PGDS inhibitor. [[http://www.ncbi.nlm.nih.gov/pubmed/16547010 Aritake K et al]] | ||
| + | ** Scientists seem to have designed ''much more potent'' H-PGDS inhibitors. [[http://www.ncbi.nlm.nih.gov/pubmed/22068479 Kamauchi S et al]] | ||
| + | ** More H-PGDS inhibitors here, but no formulae are provided ''"The formulae of the inhibitors are proprietary information"''[[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898477 Takahashi S et al]] | ||
| + | ** TFC-007 is a selective H-PGDS inhibitor. [[http://www.ncbi.nlm.nih.gov/pubmed/21601002 Nabe T et al]] | ||
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| + | * H-PGDS levels also seem to decrease rapidly (through the ubiquitin-proteasome system) when intracellular calcium is increased [[http://www.ncbi.nlm.nih.gov/pubmed/22049022 Yazaki M et al]] [[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248891/ Free full text]] | ||
| + | ** but (the required) calcium ionophores (to increase intracellular calcium locally) also seem to promote tumors. [[http://www.ncbi.nlm.nih.gov/pubmed/10469622 Kumar S et al]] | ||
Revision as of 11:57, 18 October 2012
What is male pattern baldness?
Male pattern baldness is caused by a genetic sensitivity of hair follicles to DHT. This hormone causes follicles to shrink or "miniaturize". In turn, this shortens their lifespan and prevents them from producing hair normally.
5-alpha-reductase and DHT
Men with androgenic alopecia typically have higher levels of 5-alpha-reductase, lower levels of total testosterone, higher levels of unbound/free testosterone, and higher levels of total free androgens including DHT.
PGD2
Recent research suggests that elevated levels of the enzyme prostaglandin D2 synthase and its product prostaglandin D2 (PGD2) in hair follicles causes androgenetic alopecia. [Garza A et al]
- Prostaglandin D2 synthase (Prostaglandin-H2 D-isomerase (PTGDS) = H-PGDS) converts prostaglandin H2 (PGH2) into prostaglandin D2 (PGD2), so maybe a topical inhibitor of this enzyme will do the trick (to compensate for the elevated level of this enzyme).
- HQL-79 is a well known, but relatively weak H-PGDS inhibitor. [Aritake K et al]
- Scientists seem to have designed much more potent H-PGDS inhibitors. [Kamauchi S et al]
- More H-PGDS inhibitors here, but no formulae are provided "The formulae of the inhibitors are proprietary information"[Takahashi S et al]
- TFC-007 is a selective H-PGDS inhibitor. [Nabe T et al]
- H-PGDS levels also seem to decrease rapidly (through the ubiquitin-proteasome system) when intracellular calcium is increased [Yazaki M et al] [Free full text]
- but (the required) calcium ionophores (to increase intracellular calcium locally) also seem to promote tumors. [Kumar S et al]
