Skin laxity

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Revision as of 12:03, 27 January 2015 by RRM (talk | contribs)

Skin laxity may be caused by loose skin due to

  • redundant skin after rapid weight loss
  • damaged collagen and reduced collagen production in ageing
  • reduced muscle tone due to immobility

... in combination with heavy skin due to:

  • water retention in the true skin
  • subcutaneous fat accumulation


Collagen is damaged by sunlight exposure, endogenous- and dietary AGEs/ALEs and free radicals in general. Elevated exposure will accelerate age-related exhaustion of collagen production. Solar UV irradiation causes photoaging, characterized by fragmentation and reduced production of type I collagen fibrils that provide strength to skin.[1] Long-term exposure to sunlight, including ultraviolet A and B, produces signs associated with photoaging and photodamage, including laxity.[2] Exposure to UV-B irradiation suppresses collagen synthesis. Daily life low-dose UV-A1 exposures promote photoaging by affecting collagen breakdown. Responsive darkening of the skin does not prevent UV-A1-induced collagenolytic changes.[3] Resveratrol has antioxidant properties and promotes autophagy, stimulating mitochondrial biogenesis. Topically applied Resveratrol (1%) in combination with vitamin E (1%) and baicalin (0.5%) may reduce skin laxity in 12 weeks.[4] Topically applied Pogostemon cablin may inhibit UV-induced photaging, due to its antioxidative property.[5] Radiofrequency produces thermal effects at various depths, promoting collagen remodeling while sparing the overlying tissue.[6] Precise and controlled subdermal heating may promote subdermal skin tightening.[7] Radiofrequency may be more effective than cutaneous and subcutaneous administration of CO2[8]